Prof. Ayelet Fishman


Phone: +972-4-8295898
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Prof. Ayelet Fishman


Biotechnology and Food Engineering

Main energy field:

Alternative Fuels


Ph.D.2002, Technion, Biotechnology
M.Sc.1992, Technion, Biotechnology
B.Sc.1989, Technion, Biotechnology and Food Eng.

2007-2011 – The Technion award for excellence in teaching.
2008 – The Alfred & Yehuda Wiessman award for excellence in teaching.
2011 – The Henri Gutwirth Prize for the Promotion of Research.
2011 – The Moshe Yanai prize for excellence in teaching.

Research Area in Energy:

Biotechnology based production of biodiesel.

Research Interests:

Biomass-Based Fuels; Conversion of oils to biodiesel using enzymes. Engineering enzymes for improved activity in non-aqueous media. Structure-functions studies of enzymes.

Selected Publications:

Isaschar-Ovdat, S., Rosenberg, M., Lesmes, U. and Fishman, A. (2015) Characterization of oil-in-water emulsions stabilized by tyrosinase-crosslinked soy glycinin. Food Hydrocolloid. 43:493-500.

Gefen, E.*, Talal, S., Brendzel O., Dror A. and Fishman A. (2015) Variation in quantity and composition of cuticular hydrocarbons in the scorpion Buthus occitanus (Buthidae) in response to acute exposure to desiccation stress. Comp. Biochem. Physiol., A: Comp. Physiol. Accepted.

Achmon, Y., Ben-Barak Zelas, Z. and Fishman, A. (2014) Cloning Rosa hybrid phenylacetaldehyde synthase for the production of 2-phenylethanol in a whole cell Escherichia coli system. Appl. Microbiol. Biotechnol. 98:3603-3611.

Goldfeder, M. and Fishman, A. (2014) Modulating enzyme activity using ionic liquids or surfactants. Appl. Microbiol. Biotechnol. 98:545-554.

Dror, A., Shemesh, E., Dayan, N. and Fishman, A. (2014) Engineering lipase from Geobacillus stearothermophilus for improved stability in methanol. Appl. Environ. Microbiol. 80:1515-1527.

Bernath-Levin, K., Shainsky, J., Sigawi, L. and Fishman, A. (2014) Directed evolution of nitrobenzene dioxygenase for the production of the antioxidant hydroxytyrosol. Appl. Microbiol. Biotechnol. 98:4975-4985.

Hosseini, A., Brouk, M., Lucas, M.F., Glaser, F., Fishman, A.* and Guallar, V.* (2014) An atomic picture of ligand migration in toluene 4-monooxygenase. J. Phys. Chem. B. DOI: 10.1021/jp502509a.

Goldfeder, M., Kanteev, M., Isaschar-Ovdat, S., Adir, N.* and Fishman, A.* (2014) Determination of tyrosinase substrate binding modes reveals the mechanistic differences between type-3 copper proteins. Nat. Commun. DOI 10.1038/ncomms5505.

Goldfeder, M., Egozi, M., Shuster Ben-Yosef, V., Adir, N. and Fishman, A. (2013) Changes in tyrosinase specificity by ionic liquids and SDS. Appl. Microbiol. Biotechnol. 97:1953-1961.

Goldfeder, M., Kanteev, M., Adir, N. and Fishman, A. (2013) Influencing the monophenolase/diphenolase activity ratio in tyrosinase. BBA-Proteins and Proteomics. 1834:629-633.

Shainsky, J., Bernath-Levin, K., Isaschar-Ovdat, S., Glaser, F., and Fishman, A. (2013) Protein engineering of nitrobenzene dioxygenase for enantioselective synthesis of chiral sulfoxides. Prot. Eng. Des. Select. 26:335-345. (Chosen for the cover of the issue).

Kanteev, M., Goldfeder, M., Chojnacki, M., Adir, N. and Fishman, A. (2013) The mechanism of copper uptake by tyrosinase from Bacillus megaterium. J. Biol. Inorg. Chem. 18:895-903.

Brouk M., and Fishman, A. (2012) Improving process conditions for hydroxytyrosol synthesis by toluene 4-monooxygenase. J. Mol. Catal. B:Enzymatic 84:121-127.

Dror, A., and Fishman, A. (2012) Engineering non-heme mono- and dioxygenases for biocatalysis. Comput. Structur. Biotechnol. J. 2 (3): e201209011. doi:

Sendovski, M., Kanteev, R., Shuster Ben-Yosef, V., Adir, N., and Fishman, A. (2011) First structures of Bacillus megaterium tyrosinase reveal plasticity in copper binding. J. Mol. Biol. 405:227-237.

Achmon, Y., Goldshtein, J., Margel, S., and Fishman, A. (2011) In situ removal of 2-phenylethanol from yeast fermentation using hydrophobic microspheres. J. Microencapsulation. 28:628-638.