Prof. Yuval Shoham


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Prof. Yuval Shoham


Biotechnology and Food Engineering

Main energy field:

Alternative Fuels


Ph.D. 1987, M.I.T, Biochemical Engineering.
M.Sc. 1982, Tel Aviv University, Microbiology.
B.Sc. 1980, Tel Aviv University, Biology.

2001 – 2008 Head, The Interdepartmental Program in Biotechnology, Technion.
2004 – 2007 Dean, Faculty of Biotechnology and Food Engineering.
2004 – 2007 Director, The Otto Meyerhoff Minerva Center for Biotechnology.

2009 – 2012 Deputy Executive Vice President for Research

2010 – 2012 Director, The Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering

2013 – 2016 Dean, Faculty of Biotechnology and Food Engineering

1980 B.Sc (with honors), Tel Aviv University.
1982 M.Sc (with honors), Tel Aviv University.
1990 The Muriel and David Jacknow Award for excellence in teaching.
1995 The Henry Taub Prize for Research.
1996 The Herschel Rich Technion Innovation Award.
1999 The Moshe Shilo Award from the Israel Society for Microbiology.
2001 Fellow-American Academy of Microbiology.
2002 The Eduard Rherin Science Prize of the German Technion Society.
2002 The Erwin and Rosl Pollak Chair in Biotechnology.
2007 Technion’s Excellence in Teaching Award (top 5%).
2009 The Herschel and Hilda Rich Technion Innovation Award.


Research Area in Energy:

Microbial and enzymatic degradation of the plant cell wall.

Research Interests:

Biomass-Based Fuels – Microbial and enzymatic degradation of cellulose and hemicelluloses; structure-function relationships of glycoside hydrolases and carbohydrate binding domains.

Selected Publications:

Iván Muñoz-Gutiérrez, Lizett Ortiz de Ora, Inna Rozman Grinberg, Yuval Garty, Edward A. Bayer, Yuval Shoham, Raphael Lamed and Ilya Borovok.  Decoding biomass-sensing regulons of Clostridium thermocellum alternative sigma-I factors in a heterologous Bacillus subtilis host system.  PlosOne;11(1):e0146316, 2016 Jan 5.

Svetlana Petkun, Inna Rozman Grinberg, Raphael Lamed, Sadanari Jindou, Tal Burstein, Oren Yaniv, Yuval Shoham, Linda J.W. Shimon, Edward A Bayer, Felix Frolow. Reassembly and co-crystallization of a family 9 processive endoglucanase from its component parts: Structural and functional significance of the intermodular linker. PeerJ 3:e1126, 2015.

Andy Sand, Evert K. Holwerda, Natalie M. Ruppertsberger, Marybeth Maloney, Daniel G. Olson, Yakir Nataf, Ilya Borovok, Abraham L. Sonenshein, Edward A. Bayer, Raphael Lamed, Lee R. Lynd, and Yuval Shoham. Three cellulosomal xylanase genes in C. thermocellum are regulated by both alternative SigI6 (sI6) and vegetative SigA (sA) factors.  FEBS Letters: 589:3133-3140, 2015.

Hodaya V. Solomon, Orly Tabachnikov, Shifra Lansky, Rachel Salama, Hadar Feinberg, Yuval Shoham and Gil Shoham. Structure-function relationships in Gan42B, an intracellular GH42 [beta]-galactosidase from Geobacillus stearothermophilus. Acta Cryst D71, 2433–2448, 2015.

Shifra Lansky, Onit Alalouf, Vered Solomon, Anat Alhassid, Lata Govada, Naomi Chayen, Hassan Belrhali, Yuval Shoham and Gil Shoham. A unique octameric structure of Axe2, an intracellular acetyl-xylooligosaccharide esterase from Geobacillus stearothermophilus. Acta Cryst D70:261-278, 2014.

Oren Yaniv, Galit Fichman, Ilya Borovok, Yuval Shoham, Edward Bayer, Raphael Lamed, Linda Shimon and Felix Frolow. Fine-structural variance of family 3 carbohydrate-binding modules as extracellular biomass-sensing components of Clostridium thermocellum anti-sigmaI factors.  Acta Cryst D70: 522-534, 2014.

Smadar Shulami, Ofer Shenker, Yael Langut, Noa Lavid, Orit Gat, Galia Zaide, Arik Zehavi, Abraham L. Sonenshein, and Yuval Shoham.  Multiple regulatory mechanisms control the expression of the Geobacillus stearothermophilus gene for extracellular xylanase. J. Biol. Chem 289:25957-25975, 2014.

Shifra Lansky, Rachel Salama, Hodaya V. Solomon, Hadar Feinberg, Hassan Belrhali, Yuval Shoham and Gil Shoham. Structure-specificity relationships in Abp, a GH27 β-L-arabinopyranosidase from Geobacillus stearothermophilus. Acta Cryst D70, 2994–3012, 2014.

Roie Dann, Shifra Lansky, Noa Lavid, Arik Zehavi, Valery Belakhov, Timor Baasov, Babu Manjasetty, Hassan Belrhali, Yuval Shoham and Gil Shoham. Preliminary crystallographic analysis of Xyn52B2, a GH52 [beta]-D-xylosidase from Geobacillus stearothermophilus T6. Acta Cryst F70, 1675-1683, 2014.

Orly Tabachnikov and Yuval Shoham. Functional Characterization of the Galactan Utilization System of Geobacillus stearothermophilus. FEBS J 280:950-964, 2013.

Yael Balazs, Elina Lisitsin, Oshrat Carmiel, Gil Shoham, Yuval Shoham, and Asher Schmidt. Identifying critical unrecognized sugar – protein interactions in GH10 xylanases from Geobacillus stearothermophilus using STD NMR, FEBS Journal 280:4652–4665, 2013.

Sarah Moraïs, Orly Salama-Alber, Yoav Baraka, Yitzhak Hadar, David B. Wilson, Raphael Lamed, Yuval Shoham and Edward A. Bayer. Functional association of the catalytic and ancillary modules dictates enzymatic activity in a family-43 b-xylosidase.  J. Biol. Chem. 287:9213-9221, 2012.

Steven Brown, Raphael Lamed, Ely Morag, Ilya Borovok, Yuval Shoham, Dawn Klingeman, Courtney Johnson, Zamin Yang, Miriam Land, Sagar Utturkar, and Edward Bayer. Draft genome sequences for Clostridium thermocellum wild-type Strain YS and derived cellulose adhesion-defective mutant strain AD2. J. Bacteriol 194(12):3290-1, 2012.

Rachel Salama, Onit Alalouf, Orly Tabachnikov, Gennady Zolotnitsky, Gil Shoham, Yuval Shoham.  The abp gene in Geobacillus stearothermophilus T-6 encodes a GH27 β-L-arabinopyranosidase. FEBS Lett. 586:2436–2442, 2012.

Sarah Moraïs, Ely Morag, Yoav Barak, Dan Goldman, Yitzhak Hadar, Raphael Lamed, Yuval Shoham, David B. Wilson, and Edward A. Bayer. Deconstruction of lignocellulose into soluble sugars by native and designer cellulosomes. MBio Volume 3 Issue 6 e00508-12, 2012.

Liat Bahari, Yuval GIlad, Ilya Borovok, Hamutal Kahel-Raifer, Bareket Dassa, Yakir Nataf, Yuval Shoham, Raphael Lamed, Edward A. Bayer. Glycoside hydrolases as components of putative carbohydrate biosensor proteins in Clostridium thermocellum J. Ind. Microbiol. Biotechnol. 38:825–832, 2011.

Smadar Shulami, Ayelet Raz-Pasteur, Orly Tabachnikov, Sarah Gilead-Gropper, Itzhak Shner, and Yuval Shoham. The L-arabinan utilization system of Geobacillus stearothermophilus J. Bacteriol. 193:2838-2850, 2011.

Sarah Moraïs, Yoav Barak, Yitzhak Hadar, David Wilson, Yuval Shoham, Raphael Lamed, and Edward Bayer.  Assembly of xylanases into designer cellulosomes promotes efficient hydrolysis of the xylan component of a natural recalcitrant cellulosic substrate. MBio 2(6):e00233-11, 2011.

Onit Alalouf, Yael Balazs, Margarita Volkinshtein, Yael Grimpel, Gil Shoham, Yuval Shoham.  A new family of carbohydrate esterases is represented by a GDSL/acetylxylan esterase from Geobacillus stearothermophilus.  J. Biol. Chem. 286:41993-42001, 2011.

Sarah Moraïs, Yoav Barak, Jonathan Caspi, Yitzhak Hadar, Raphael Lamed, Yuval Shoham, David B. Wilson, and Edward A. Bayer.  Degradation of a complex cellulosic substrate by designer cellulosomes: Contribution of a xylan-binding module. Appl. Enviorn. Microbiol. 76:3787-3796, 2010.

Borovok, Ilya, Hamutal Kahel-Raifer, Sadanari Jindou Liat Bahari, Yakir Nataf, Yuval Shoham, Edward Bayer, Raphael Lamed. Unique set of putative membrane-associated anti-sigma factors in Clostridium thermocellum suggests a novel extracellular carbohydrate-sensing mechanism involved in gene regulation. FEMS Microbiol. Lett. 308:84–93, 2010.

Yakir Nataf, Liat Bahari, Hamutal Kahel-Raifer, Ilya Borovok, Raphael Lamed, Edward A. Bayer, Abraham L. Sonenshein and Yuval Shoham. Clostridium thermocellum cellulosomal genes are regulated by extracytoplasmic polysaccharides via alternative sigma factors.  Proc. Natl. Acad. Sci. USA 107:18646–18651, 2010.

Sarah Moraïsa, Yoav Barak, Jonathan Caspia, Yitzhak Hadar, Raphael Lamed, Yuval Shoham, David B. Wilson, and Edward A. Bayer.  Cellulase-xylanase synergy in designer cellulosome for enhanced degradation of a complex cellulosic substrate. mBio 1(5):e00285-10. doi:10.1128/mBio.00285-10, 2010.

Yakir Nataf, Sima Yaron, Frank Stahl, Raphael Lamed, Edward A. Bayer, Thomas-Helmut Scheper, Abraham L. Sonenshein, and Yuval Shoham.  Cellodextrin and laminaribiose ABC transporters in Clostridium thermocellum. J. Bacteriol. 191:203-209, 2009.

Tal Burstein, Michal Shulman, Sadanari Jindou, Svetlana Petkun, Felix Frolow, Yuval Shoham, Edward A. Bayer, and Raphael Lamed.  Physical association of the catalytic and helper modules of a family-9 glycoside hydrolase is essential for activity.  FEBS Lett. 583:879-884, 2009.

Anat Alhassid, Alon Ben-David, Orly Tabachnikov, Dima Libster, Einat Naveh, Gennady Zolotnitsky, Yuval Shoham, and Gil Shoham. Crystal structure of an inverting GH43 1,5-α-L-arabinanase from Geobacillus stearothermophilus complexed with its substrate.  Biochem. J. 422:73-82, 2009.

Alon Karpol, Yoav Barak, Raphael Lamed, Yuval Shoham and Edward A. Bayer.  Functional asymmetry in cohesin binding belies inherent symmetry of the dockerin module: Insight into cellulosome assembly revealed by systematic mutagenesis. Biochem. J. 410:331-338, 2008

Haimovitz, Rachel, Yoav Barak, Ely Morag, Yuval Shoham, Milana Voronov-Goldman, Raphael Lamed, and Edward A. Bayer. Cohesin-dockerin microarray: diverse specificities between two complementary families of interacting protein modules. Proteomics. 8:968-979, 2008

Smadar Shulami, Galia Zaide, Gennady Zolotnitsky, Yael Langut, Geoff Feld, Abraham L. Sonenshein and Yuval Shoham. A two-component system regulates the expression of an ABC transporter for xylo-oligosaccharides in Geobacillus stearothermophilus.  Appl. Enviorn. Microbiol. 73:874-884, 2007.

Solomon, V., A. Teplitsky, S. Shulami, G. Zolotnitsky, Y. Shoham, and G. Shoham. Structure-specificity relationships of an intracellular xylanase from Geobacillus stearothermophilus. Acta Cryst. D63:845-859, 2007.

Sadanari Jindou, Qi Xu, Rina Kenig, Michal Shulman, Yuval Shoham, Edward Bayer, and Raphael Lamed.  Novel architecture of family-9 glycoside hydrolases identified in cellulosomal enzymes of Acetivibrio cellulolyticus and Clostridium thermocellum. FEMS Lett. 254:308-316, 2006.

Christian Brüx, Alon Ben-David, Dalia Shallom-Shezifi, Maya Leon, Karsten Niefind, Gil Shoham, Yuval Shoham, Dietmar Schomburg. The structure of an inverting GH43 b-xylosidase from Geobacillus stearothermophilus with its substrate reveals the role of the three catalytic residues. J. Mol. Biol. 359:97-109 2006.

Jonathan Caspi, Diana Irwin, Raphael Lamed, Yuval Shoham, Henri-Pierre Fierobe, David B. Wilson, and Edward A. Bayer.  Thermobifida fusca family-6 cellulases as potential designer cellulosome components. Biocatalysis and Biotransformation 24:3-12, 2006.